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Contact: Xiaowen Liu [liuxiaowencs (at) gmail.com]
Summary
Because of advances in protein separation and mass spectrometry, top-down mass spectrometry moved from analyzing single proteins to analyzing complex samples and identifying hundreds and even thousands of proteins. However, computational tools for database search of top-down spectra against protein databases are still in their infancy. MS-Align+ is a fast algorithm for top-down protein identification based on spectral alignment that enables searches for unexpected post-translational modifications.
Protein Identification Using Top-Down Spectra
Xiaowen Liu, Yakov Sirotkin, Yufeng Shen, Gordon Anderson, Yihsuan S. Tsai,
Ying S. Ting, David R. Goodlett, Richard D. Smith, Vineet Bafna,
and Pavel A. Pevzner
Molecular & Cellular Proteomics, 11,M111.008524.